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Young-Onset, ROS1-Rearranged Adenocarcinoma of the Lung With Cardiac Tamponade: A Case Report

Year: 2024

Type: article

Abstract: Adenocarcinoma with ROS1 rearrangement is rare. Carcinomatous pericarditis is generally seen in advanced stages and is a life-threatening condition. A 21-year-old male was admitted to our hospital because of severe dyspnea due to cardiac tamponade identified on echocardiography. A diagnosis of ROS1-rearranged adenocarcinoma of the lung was made from the pathological and gene mutation analyses of the cell block from his pericardial fluid. Oral administration of entrectinib was highly effective, and his serum carcinoembryonic antigen (CEA) level improved from 247 to 10.8 ng/mL. The present case has clinical significance because a pathological and genetic diagnosis was made from the pericardial effusion fluid, and the clinical manifestations of cardiac tamponade due to lung cancer were well controlled by the administration of entrectinib.

Source: Cureus

DOI: 10.7759/cureus.71777

Authors: Masafumi Nojiri, Ryudai Abe, Sumito Nagae, Takuya Tanaka, Yutaka Takahara

Institution: Kanazawa Medical University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403538743