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Blood expression of NADK2 as a diagnostic biomarker for sciatica

Year: 2024
Type: article
Study design: Observational Study
Abstract: Sciatica is characterized by radiating pain along the sciatic nerve, with a lifetime prevalence of up to 43%. This study explored blood biomarkers for sciatica using transcriptomic microarray data (GSE124272 and GSE150408). Differential gene expression analysis identified NADK2 as a potential diagnostic biomarker. A diagnostic model based on NADK2 showed strong validation performance in 200 clinical cases. Gene set enrichment analysis (GSEA) suggested a connection between NADK2 and the aminoacyl-tRNA biosynthesis pathway. In conclusion, NADK2 emerges as promising diagnostic and therapeutic targets for sciatica, significantly advancing our comprehension of potential pathogenic mechanisms and offering perspectives for early diagnosis and treatment.
Source: iScience
DOI: 10.1016/j.isci.2024.111196
Authors: Xiaobo Wang, Zhenxiao Ren, Bingyu Wang, Jiawei Shi, Jingmin Liu, Yang Wang, Xin Zheng
Institutions: Nanfang Hospital, Southern Medical University, Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou Medical University, Zhujiang Hospital, First Affiliated Hospital Zhejiang University
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,150
OpenAlex ID: W4403540667
FWCI: 0.797
Cites: 46
Cited by: 3
Related to: 10