Factors affecting time to recovery from diabetic ketoacidosis in adult diabetic patients in Alexandria Main University Hospital
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background Diabetic ketoacidosis (DKA) is a life-threatening condition as a complication of diabetes and represents a significant healthcare global burden. The current study goal was to determine factors affecting time to recovery from DKA in Alexandria Main University Hospital. Patients and methods: 150 patients who had been admitted with DKA were included in this study. All patients were managed with hospitalization for IV fluids, continuous intravenous insulin infusion, electrolytes correction, as well as detection and treatment of the predisposing factor until the full resolution of DKA. Results Males contributed to (58.7%) of the total patients in this study with a mean age of (32.16 ± 15.06) years. DKA mean time of resolution was (18.76 ± 14.07) hours. The majority of patients were with T1DM (86%), while T2DM were (14%). Missed insulin dose was the leading precipitating factor (60.7%) followed by infections (38.7%). There was a statistically significant relationship between DKA resolution time with age, time of presentation, type of diabetes, initial PH, initial serum K+ level, initial HCO3− level, initial anion gap, initial base excess, and initial RBS. (p value < 0.001). Conclusion Delayed time of resolution from DKA was associated with initial lower PH, initial lower HCO3− level, initial lower base excess level, initial higher anion gap level, type 2 diabetes mellitus, patients on pre-mixed insulin regimen, old patients, delayed time for seeking medical care, and abnormal serum K+ level.
Institution: Alexandria University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403545418