Year: 2024
Type: article
Abstract: Breast cancer, a prevalent and significant health issue among women, is influenced by genetic, environmental, and lifestyle factors. Treatment often involves the AC/T regimen (Adriamycin, Cyclophosphamide, and Paclitaxel), which presents dosage challenges due to toxicity and therapeutic window limitations. This review focuses on the role of Therapeutic Drug Monitoring (TDM) in optimizing AC/T regimen doses to enhance efficacy and reduce side effects. TDM's impact on improving clinical outcomes is discussed, especially with targeted therapies like tyrosine kinase inhibitors and immunosuppressants. Adriamycin's DNA intercalation, Cyclophosphamide’s DNA alkylation, and Paclitaxel’s microtubule stabilization illustrate varied mechanisms of action that benefit from TDM for dose personalization. This analysis highlights TDM's potential in reducing adverse effects while maximizing therapeutic impact in breast cancer treatment.
Author: Smitha Sarah Thambi
Institution: Vinayaka Missions University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4403545742