Get started
Work

Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination

Year: 2024
Type: article
Study design: Observational Study
Abstract: Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and vaccinated individuals at 1 and 8 months postexposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naive persons at 1 month postexposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study suggests that additional vaccine strategies are needed to elicit a durable humoral response and prevent breakthrough infections.
DOI: 10.1093/infdis/jiae515
Authors: Christopher N Selverian, Stephanie R Monticelli, Yakin M Jaleta, Gorka Lasso, Megan E DeMouth, Annalisa Meola, Jacob Berrigan, Thomas G Batchelor, Leandro Battini, Pablo Guardado-Calvo, Andrew S Herbert, Kartik Chandran, Eric Meyerowitz, Emily Happy Miller
Institutions: Albert Einstein College of Medicine, United States Army Medical Research Institute of Infectious Diseases, The Geneva Foundation, Institut Pasteur, Université Paris Cité, Department of Virology, Oak Ridge Institute for Science and Education, Montefiore Medical Center
Language: English
Subfield: Virology
Open Access status: bronze
OpenAlex ID: W4403546322
FWCI: 2.904
Cites: 15
Cited by: 14
Related to: 10