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Figure 3 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Year: 2024

Type: other

Abstract: IFN-β induction after TLR1/2 stimulation associates with PBMC ELISpot responses to Fluzone, PHA, and CEFT (cytomegalovirus, EBV, Fluzone, and Tetanus peptide pool). A, ELISpot SFU after each indicated stimulant (n = 77 CEFT, n = 79 Fluzone, n = 82 for others). B, Cell type–specific PBMC densities as a percentage of live single cells (bottom) separated by median IFN-β response after TLR1/2 stimulation (n = 106, PRIME study). A and B,P values are from unpaired t test; mean + SEM is shown. C, Correlation (Spearman r) of each indicated PBMC (ELISpot), serum (ELISA), or sip-T product metric (CD54 upreg and TNC) output with fold mock IFN-β values after TLR1/2 stimulation; (*) indicates FDR adjusted Q < 0.05. See Supplementary Figs. S4 and S5 for extended data and representative gating. SFU, spot forming units.

DOI: 10.1158/2767-9764.27255855

Authors: Michael C. Brown, Vincent M. D’Anniballe, David Boczkowski, Harini Kandadi, Nadeem Sheikh, William Kornahrens, Elisabeth I. Heath, Archana Thakur, Wei Chen, Lawrence Lum, Frank C. Cackowski, Julie Boerner, Michael D. Gunn, Andrew J. Armstrong, Smita K. Nair

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4403546791

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