How the heterogeneity of the severely injured brain affects hybrid diffuse optical signals: case examples and guidelines
Year: 2024
Type: article
Abstract: Significance: A shortcoming of the routine clinical use of diffuse optics (DO) in the injured head has been that the results from commercial near-infrared spectroscopy-based devices are not reproducible, often give physiologically invalid values, and differ among systems. Besides the limitations due to the physics of continuous-wave light sources, one culprit is the head heterogeneity and the underlying morphological and functional abnormalities of the probed tissue. Aim: The aim is to investigate the effect that different tissue alterations in the damaged head have on DO signals and provide guidelines to avoid data misinterpretation. Approach: DO measurements and computed tomography scans were acquired on brain-injured patients. The relationship between the signals and the underlying tissue types was classified on a case-by-case basis. Results: Examples and suggestions to establish quality control routines were provided. The findings suggested guidelines for carrying out DO measurements and speculations toward improved devices. Conclusions: quality control routines that go beyond an assessment of the signal-to-noise ratio that is typically utilized.
Source: Neurophotonics
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,675
Funders: Fundació la Marató de TV3, Centres de Recerca de Catalunya, Laserlab-Europe, European Commission, Generalitat de Catalunya, Fundació Institut de Recerca Hospital Universitari Vall d’Hebron, Horizon 2020 Framework Programme, Agència de Gestió d'Ajuts Universitaris i de Recerca, Agencia Estatal de Investigación
Awards: G1153010057, G1175115578, G1908469581, G1991580874, G2064873908, G210041235, G2262748287, G2496945670, G2509333814, G2601397997, G265104915, G2763573136, G288263039, G3005324705, G300979063, G34346518, G3480869486, G3681454997, The Integrated Initiative of European Laser Research Infrastructures, G4042783231, G425668148, G4303546637, G434337789, G4937468798, G5080475149, G5085471144, G5091331727, G5175525644, G5651447409, G5852091828, PORTABLE PLATFORM FOR THE ASSESSMENT OF MICROVASCULAR HEALTH IN COVID-19 PATIENTS AT THE INTENSIVE CARE, G6297772267, G6482940084, MICROARRAYS FOR THE DETECTION OF TOXIC ALGAE, G6538096437, G6656126374, G683931746, G69051668, G6947511255, G7084143925, G7425137858, G8180681537, G8306836627, G8671823837, G8684520763, BIO-PHOTONIC IMAGING OF THE INFANT BRAIN, THE MISSING LINK BETWEEN THE CELLULAR BRAIN DAMAGE AND THE NEUROVASCULAR UNIT DURING ACUTE ILLNESS, Brain injury and trauma monitoring using advanced photonics
OpenAlex ID: W4403546834