Figure 4 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T
Year: 2024
Type: other
Abstract: Black race and TLR1-602I SNP associate with stronger responses to TLR1/2 stimulation. A, Supernatant cytokine release separated by Black (n = 15) vs. White (n = 91) for each stimulation normalized to fold mock treatment control in the PRIME study; (*) Mann–Whitney test P < 0.05. B, TLR1-602 genotypes for each patient with sufficient DNA (n = 88 White; n = 15 Black) were tested by PCR-RFLP; percentages of I/I or I/S vs. S/S by race are shown. C, Mean fold mock control cytokine induction by genotype is shown for each stimulus; asterisks indicate significant FDR-corrected unpaired t tests Q < 0.05 (two-tailed). D, Mean fold mock control TLR1/2 induced cytokine induction by genotype for White vs. Black (all I/I or I/S); FDR-adjusted unpaired t test Q < 0.05 vs. White S/S (*) or vs. all other groups (#). E, Heatmaps depict −log (P values) from comparisons in B (cytokine induction by race) or C (cytokine induction by TLR1 SNP status) for each cytokine and treatment. See Supplementary Fig. S6 for extended data.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4403547138