Work

A rare case of PDGFRA-positive chronic eosinophilic leukemia

Year: 2024

Type: article

Abstract: ABSTRACT: Chronic eosinophilic leukemia (CEL) is a clonal proliferation of eosinophilic precursors resulting in a persistently elevated number of eosinophils in blood, bone marrow, and peripheral tissues. The vaguely overlapping clinicopathological picture of CEL with idiopathic hypereosinophilic syndrome (IHES) often adds to the diagnostic dilemma. Here, we report a rare case of 49-year-old male who presented with multiorgan damage. Peripheral blood smear revealed predominantly eosinophils with dysplastic changes, shift to left in eosinophilic series, and 2% blasts. The bone marrow showed 5% blasts and many eosinophils, precursors of eosinophils, and myeloid and megakaryocytic proliferation. Till date, CEL is a very rare entity. Its presentation with cardiac and neurological manifestations is still rare.

Source: Indian Journal of Pathology and Microbiology

DOI: 10.4103/ijpm.ijpm_872_23

Authors: Kalpana Bothale, Akanksha Salkar, Amit Salkar

Institution: NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital

Language: English

Topic: Eosinophilic Disorders and Syndromes

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200