Work

KSCN‐Mediated One‐Pot Thiocyanation Tandem Cyclization of Enaminones: a Facile Access to 2‐amino/imino Thiazolo Fused Chromone and Coumarin Frameworks

Year: 2024

Type: article

Abstract: A rapid metal‐free approach describing one‐pot thiocyanation of chromone and coumarin enabling tandem cyclization via potassium thiocyanate as a sulfur surrogate was unveiled. Interestingly, this enaminone‐mediated protocol facilitated straightforward access to medicinally significant 2‐amino/imino thiazolo fused chromone and coumarin frameworks. This methodology provided good atom‐economy, remarkable functional group tolerance, and scalability. Alongside establishing a wide substrate scope, it also provided a feasible scalability up to gram scale.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202400690

Authors: Akshay Kumawat, Sumbul Mansuri, Mary Sravani Galla, Nagula Shankaraiah

Institution: National Institute of Pharmaceutical Education and Research

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4403551408

FWCI: 0.706

Cites: 26

Cited by: 5

Related to: 10