Work

Toxoplasmosis-Associated Hemophagocytic Lymphohistiocytosis in a Liver Transplant Recipient

Year: 2024

Type: article

Abstract: Toxoplasmosis is a rare parasitic infectious disease in solid organ transplant recipients. The disease is characterized by difficulties in diagnosis and high mortality. However, there have been no reported cases of hemophagocytic lymphohistiocytosis (HLH) caused by toxoplasmosis in liver transplant patients. Here, we present the case of an adult female liver transplant recipient who experienced a fatal outcome and developed secondary HLH following confirmation of toxoplasmosis through metagenomic next-generation sequencing. The patient exhibited symptoms, including high fever, skin rash, unconsciousness, and multiorgan failure. The condition met six out of eight criteria for HLH according to the HLH-2004 diagnostic criteria. Additionally, the H-score for this patient was 287 points, confirming the diagnosis of HLH. This represents the first reported case of toxoplasmosis-associated secondary HLH in an adult liver transplant recipient in China.

Source: Cureus

DOI: 10.7759/cureus.71843

Authors: Yu Gong, Ting Wang

Institutions: Shanghai Medical College of Fudan University, Fudan University, Zhongshan Hospital

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Fudan University