Work

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Year: 2024

Type: article

Abstract: A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4- b ]indole-1,5(3 H )-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks from indole-2-carboxamides and 4-hydroxy-2-alkynoates. This method provides a direct access to fused carbolines that are closely resemble to biologically active β -carboline frameworks.

Source: Tetrahedron Chem

DOI: 10.1016/j.tchem.2024.100104

Authors: Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy

Institutions: Indian Institute of Chemical Technology, Academy of Scientific and Innovative Research

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4403559235

FWCI: 0.706

Cites: 55

Cited by: 5

Related to: 10