Work

First Report of Response to Tarlatamab in a Patient With DLL3-Positive Pulmonary Carcinoid: Case Report

Year: 2024

Type: article

Abstract: Tarlatamab, a DLL3-targeting bispecific T-cell engager, has rapidly assumed the role of a new standard of care in the later-line treatment of extensive-stage SCLC. Little is known about the efficacy of tarlatamab in other histologies such as DLL3-expressing metastatic pulmonary carcinoid tumor, a clinical entity without many approved management options. Here, we report the case of a patient with metastatic atypical carcinoid tumor which had progressed on multiple previous therapies. Her tumor strongly expressed DLL3 protein and had clinical response to tarlatamab therapy. This case indicates that this novel therapy may be an efficacious option in other pulmonary neuroendocrine cancers.

Source: JTO Clinical and Research Reports

DOI: 10.1016/j.jtocrr.2024.100750

Authors: Alissa J. Cooper, Natasha Rekhtman, Marina K. Baine, Marie C. Thomas, Alia C. Lynch, Ryan D. Gentzler

Institutions: Memorial Sloan Kettering Cancer Center, University of Virginia Medical Center, University of Virginia Cancer Center, University of Virginia

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000