Year: 2024
Type: article
Study design: Case Report
Abstract: Merkel cell carcinoma (MCC) is a very rare aggressive malignant tumor.Risk factors include older age, exposure to ultraviolet radiation, immunodeficiency status, and infection with Merkel cell polyomavirus (MCPyV).MCC not been considered to run in families, and a review of the medical literature failed to reveal any cases of MCC in first-degree relatives.The aim of this report was to describe for the first time the development of MCC in two brothers.The extremely low likelihood of siblings acquiring the disease, compounded by the similar clinical presentation of the tumor on the skin of the right thigh in both brothers, suggests a possible unknown predisposing factor.Genetic predisposition analysis should be performed in family members of patients with MCC.
Source: Annals of Case Reports
Authors: Shlomit Fennig, Elena Didkovsky, Eyal Fenig
Institutions: Kaplan Medical Center, Tel Aviv University, Rabin Medical Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403566823