Work

Optimizing PD-L1/PD-1 therapies: Immune checkpoint inhibitors in nasopharyngeal carcinoma

Year: 2024

Type: article

Abstract: • Mechanistic Insights : This article delves into the molecular mechanisms of PD-L1 and PD-1 interactions, elucidating how these immune checkpoints regulate T-cell activity in the tumor microenvironment of nasopharyngeal carcinoma. • Therapeutic Strategies : It discusses various strategies for optimizing PD-L1/PD-1 therapies, including combination therapies with chemotherapy, radiotherapy, and other immunotherapeutic agents to enhance efficacy and overcome resistance. • Clinical Outcomes : The review evaluates clinical trial data and real-world outcomes of PD-L1/PD-1 inhibitors in nasopharyngeal carcinoma, highlighting the potential for improved survival rates and quality of life for patients. • Future Directions : It outlines emerging biomarkers and personalized approaches for patient selection, aiming to maximize the benefits of immune checkpoint inhibitors in treating nasopharyngeal carcinoma.

Source: Oral Oncology Reports

DOI: 10.1016/j.oor.2024.100675

Authors: Madhan Krishnan, Gayathri Sekar

Institution: Chettinad Academy of Research and Education

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100