Year: 2024
Type: article
Study design: Case Report
Abstract: Mesenteric fibromatosis (MF) and gastrointestinal stromal tumor (GIST) are distinct types of lesions that are often mistaken for one another. Fibromatosis of the stomach is a rare condition that can be misdiagnosed as GIST, with MF accounting for only 0.3% of all tumors. Due to its rarity, accurately identifying and appropriately treating this condition poses a significant challenge. Here, we report a case of a 45-year-old female who presented with multiple episodes of vomiting after food intake. Initial radiological investigations suggested a diagnosis of GIST. However, histopathological examination of the surgical excision specimen confirmed fibromatosis with a keloid pattern. Beta-catenin is a key marker for MF; although immunohistochemistry markers were negative for beta-catenin in this case, it is important to note that beta-catenin positivity is observed in only 70-80% of cases. Differentiating these two distinct tumors can be challenging due to potential overlaps in clinical presentation, macroscopic appearance, and even histological features.
Source: Cureus
DOI: 10.7759/cureus.71915
Authors: Alekhya Madisetty, Mohana Priya, Kishor R J, Mahin Nallasivan, Arumugam Vasugi
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403572489