Work

Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities

Year: 2024

Type: article

Abstract: Three new neoclerodane diterpenoids ( 1–3 ), two new steroids ( 4–5 ), one new monoterpene ( 6 ), one new derivative of benzaldehyde ( 7 ) and one new iridoid glycoside ( 8 ), along with 19 known phenolic compounds, were isolated from Clerodendrum trichotomum . Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on α -glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR- γ ) agonist activities, and the results showed that three phenylethanoid glycosides , verbascoside ( 9 ), leucosceptoside a ( 10 ), and isoacteoside ( 13 ), and two flavonoids , apigenin ( 22 ) and luteolin ( 26 ) showed potent inhibitory effects against α-glucosidase, with IC 50 values in the range from 15 to 700 μM. In addition, four flavonoids apigenin 7 -O-β -D-glucuronide ( 19 ), apigenin ( 22 ), luteolin ( 26 ), and quercetin ( 27 ) exhibited significant PPAR- γ agonistic activities with EC 50 values in the range 2.3–24.9 μM.

Source: Fitoterapia

DOI: 10.1016/j.fitote.2024.106266