Year: 2024
Type: article
Study design: Observational Study
Abstract: . Purpose: to explore the features of the structure of intracoronary thrombi obtained during manual thromboaspiration as part of primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods. The study included 100 patients with STEMI. All of them underwent stenting preceded by manual thromboaspiration. The obtained material was fixed in formalin and stained with hematoxylin-eosin and orange-red-blue (Zerbino- Lukasiewicz method). Results. Based on the fibrin age assessment, the thrombi were old or fresh. Some thrombi showed signs of organization in the form of microchannels. Homogeneous and layered thrombi were distinguished by structure. Sometimes there were pronounced signs of neutrophil infiltration, mainly along the periphery of the thrombus. Occasionally, components of atherosclerotic plaque were found in intracoronary thrombi. Most often these were cholesterol crystals and foam cells. Conclusions. Intracoronary thrombi formed in STEMI have different ages and different structural features. This is probably due to the peculiarities of the pathogenesis of the disease.
Source: Kharkiv Surgical School
Author: D. I. Besh
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4403575869