Work

Elevated temperature increases the susceptibility of D. magna to environmental mixtures of carbamazepine, tramadol and citalopram

Year: 2024

Type: article

Abstract: The joint risks assessment of thermal stress and rising loads of pharmaceuticals (PhACs) in surface waters is a relevant topic in aquatic ecotoxicology. This study investigated the relevance of increased water temperature to alter the acute toxicity of environmentally relevant carbamazepine (CBZ), citalopram (CIT) and tramadol (TRA) concentrations as mixtures (ECs) and delayed outcomes in Daphnia magna . Responses of detoxification and antioxidant pathways in premature daphnids post an acute 24 h (pulsed) exposure to the PhACs mixtures and delayed responses as the reproductive output over 14 days recovery were investigated under 21- and 26 °C incubation. Biphasic modulation in glutathione S-transferase (GST) activity and significant inhibition of superoxide dismutase (SOD) activity were observed in both thermal regimes with significant shift in effective thresholds from 10-fold ECs at 21 °C to ECs at 26 °C incubation. Significant induction in catalase (CAT) activity and oxidative stress development were recorded at elevated temperatures from the 10-fold ECs dose onward. Pulsed exposures at 26 °C also led to significant decrease in the reproduction of daphnids above the 10-fold ECs of PhACs. The Integrated Biomarker Response scoring (IBRv2) approach outlined a 1.8-fold increase in alterations of daphnids exposed to 100-fold ECs of PhACs at 26 °C. • Elevated temperature enhances the acute toxicity of PhACs mixtures to Daphnia magna . • Exposure of daphnids at 21 °C to PhACs mixtures caused minor metabolic alterations. • Exposure of daphnids at 26 °C to PhACs mixtures led to an oxidative stress state. • Exposure of daphnids at 26 °C impaired the reproduction post-acute exposure. • Integrative Biomarker Response index outlined thermal stress boosted drug toxicity.

Source: Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology

DOI: 10.1016/j.cbpc.2024.110052

Authors: András Ács, János Schmidt, Zoltán Németh, István Fodor, Anna Farkas

Institutions: HUN-REN Balaton Limnological Research Institute, University of Pecs, Hungarian Research Network

Language: English

Topic: Pharmaceutical and Antibiotic Environmental Impacts

Subfield: Pollution

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,120