LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by a malfunction of the body's immune defense system. OBJECTIVE: The objective of the present investigation was to examine the expression and diagnostic significance of NRIR in SLE and to prove whether it is involved in the progression of SLE. METHODS: The study involved 110 participants, including 55 healthy individuals and 55 SLE patients. The expression levels of NRIR, miR-31-5p, and ICAM-1 were measured using qRT-PCR. The ROC curve was performed to assess the diagnostic significance of NRIR in SLE patients. Pearson correlation analysis was utilized to explore the relationship between NRIR and other indicators. Cytokines including IL-4, IL-6, and IL-21, along with IgG levels, were assessed using ELISA. The interaction between NRIR and miR-31-5p was validated using a dual-luciferase reporter assay. RESULT: T cells within SLE patients. NRIR could negatively modulate the expression of miR-31-5p. CONCLUSION: LncRNA NRIR may be a potential biomarker for SLE and is likely involved in the progression of SLE.
Source: Lupus
Authors: Qingfeng Ma, Li Li, Youzhong Xing
Institution: Jinan Central Hospital
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4403616068