Work

N-Alkyl Isofagomine Lactams: Synthesis, Glycosidase Inhibition, and Antimicrobial Assessments

Year: 2024

Type: article

Abstract: A series of six N-alkyl isofagomine lactam derivatives is synthesized over ten steps from d-arabinose. The compounds are evaluated as glycosidase inhibitors. It was found that the N-alkyl groups have a detrimental effect on the glycosidase inhibition activities, as the prepared N-alkyl isofagomine lactam derivatives are much less potent glycosidase inhibitors than native isofagomine lactam.

Source: Synthesis

DOI: 10.1055/s-0043-1773494

Authors: Óscar López, Emil Lindbäck, Monika Moreń, Ana Laura Pereira Lourenço, Marta Cerdà-Cuéllar, Karl Kochanowski, Kåre B. Jørgensen, Magne O. Sydnes

Institutions: Universidad de Sevilla, University of Stavanger, Centre de Recerca en Sanitat Animal, Animal Health Research Center, University of Bergen

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Universitetet i Stavanger, Ministerio de Ciencia e Innovación, HORIZON EUROPE Framework Programme

Awards: G3726571666, G5734762321

OpenAlex ID: W4403628334

FWCI: 0.139

Cites: 23

Cited by: 1

Related to: 10