Work

Mechanical memory based biofabrication of hierarchical elastic cardiac tissue

Year: 2024

Type: article

Abstract: Mimicking the multilayered, anisotropic, elastic structure of cardiac tissues for controlled guidiance of 3D cellular orientation is essential in designing bionic scaffolds for cardiac tissue biofabrication. Here, a hierarchically organized, anisotropic, wavy and conductive polycaprolactone/Au scaffold was created in a facile fashion based on mechanical memory during fabrication. The bionic 3D scaffold shows good biocompatibility, excellent biomimetic mechanical properties that guide myoblast alignment, support the hyperelastic behavior observed in native cardiac muscle tissue, and promote myotube maturation, which holds potential for cardiac muscle engineering and the establishment of an in vitro culture platform for drug screening.

Source: Biofabrication

DOI: 10.1088/1758-5090/ad89fd

Authors: Zhitong Li, Panna Kovács, Alice Le Friec, Bjarke Nørrehvedde Jensen, Jens Vinge Nygaard, Menglin Chen

Institutions: Aarhus University, Harbin Institute of Technology

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,800