Work

Longitudinal microcomputed tomography detects onset and progression of pulmonary fibrosis in conditional Nedd4-2 deficient mice

Year: 2024

Type: article

Abstract: IPF diagnosis, particularly in early stages, remains challenging. In this study, micro-CT is used in conditional Nedd4-2−/− mice to closely monitor the onset and progression of progressive pulmonary fibrosis in vivo. Together with high-resolution post mortem micro-CT, this allowed us to track how nonspecific lung lesions develop into key IPF-like features. This approach offers a noninvasive method to monitor pulmonary fibrosis, providing a quantitative endpoint for the preclinical evaluation of novel antifibrotic strategies.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00280.2023

Authors: Dominik H. W. Leitz, Philip Konietzke, Willi L. Wagner, Mara Mertiny, Claudia Benke, Thomas Schneider, Rory E. Morty, Christian Dullin, Wolfram Stiller, Hans-Ulrich Kauczor, Marcus A. Mall, Julia Duerr, Mark O. Wielpütz

Institutions: German Center for Lung Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin, Heidelberg University, University Hospital Heidelberg, Universitätsmedizin Göttingen, Max Planck Institute for Multidisciplinary Sciences, University of Göttingen, Stiftung Charité

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung

Awards: G2244354529, G2834245994, G292204839, SFB 1449: Dynamische Hydrogele an Biogrenzflächen

OpenAlex ID: W4403629112

FWCI: 1.021

Cites: 52

Cited by: 4

Related to: 10