Work

Effects of spontaneous curvature on interfacial adsorption and collapse of phospholipid monolayers

Year: 2024

Type: article

Abstract: Pulmonary surfactant must adsorb rapidly to the surface of the alveolar liquid but collapse slowly when compressed. Prior studies show that cylindrical monolayers of the inverse hexagonal phase adsorb rapidly. These structures have negative curvature; the hydrophilic face of the phospholipid leaflet is concave. Our studies tested whether planar lamellar structures with a greater tendency to form negative curvature would adsorb rapidly but collapse slowly. Compositional change accelerated adsorption but also yielded faster collapse.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00193.2024

Authors: Bret A. Brandner, Shankar B. Rananavare, Stephen B. Hall

Institutions: Oregon Health & Science University, Portland State University

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, NHLBI Division of Intramural Research

Awards: G2740349268, G7592052379, A Synchrotron Radiation Structural Biology Resource