The Application of Untargeted Metabolomic Approaches for the Search of Common Bioavailable Metabolites in Human Plasma Samples from Lippia citriodora and Olea europaea Extracts
Year: 2024
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Lippia citriodora and Olea europaea are known for their shared common bioactivities. Although both matrices are rich in similar families of bioactive compounds, their specific phytochemical compounds are mostly different. Since these compounds can be metabolized in the organism, this study hypothesized that common bioavailable metabolites may contribute to their similar bioactive effects. To test this, an acute double-blind intervention study in humans was conducted with blood samples collected at multiple time points. Using an untargeted metabolomic approach based on HPLC-ESI-QTOF-MS, 66 circulating metabolites were detected, including 9 common to both extracts, such as homovanillic acid sulfate and glucuronide derivates, hydroxytyrosol sulfate, etc. These common metabolites displayed significantly different T max values depending on the source, suggesting distinct metabolization pathways for each extract. The study highlights how shared bioavailable metabolites may underlie similar bioactivities observed between these two plant sources.
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: International Business Machines Corporation, Ministerio de Ciencia, Innovación y Universidades, Generalitat Valenciana, Ministerio de Ciencia e Innovación, Universidad de Granada, Agencia Estatal de Investigación, Agència Valenciana de la Innovació, Consejería de Agricultura, Pesca, Agua y Desarollo Rural, Junta de Andalucía
Awards: G1007137245, G1169692549, G1175115578, G1289556097, G1422035950, G1561925909, G1919634401, G1963464355, G2262748287, G2390397592, G297025776, G3004759355, G300979063, G3101456900, G3220251042, G34346518, G3480869486, G3511990098, G3520886786, G3565621276, G3662190717, G3857581125, G425668148, G4526231891, G4694513774, G4849578740, G5080475149, G5086048879, G5338730000, G5417503410, G5560852248, G586857820, G6092869561, G6352853368, G649968077, G66099019, G7084143925, G7434936867, G756240950, G792975244, G8341797944
OpenAlex ID: W4403632314