Year: 2024
Type: article
Abstract: In response to the Covid-19 pandemic, the National Heart, Lung, and Blood Institute launched five multisite clinical trials testing candidate host tissue-directed medical interventions to hasten recovery, improve function, and reduce morbidity and mortality. Speed, flexibility, and collaboration were essential. This article from the Steering and Executive committees describes the Collaborating Network of Networks for Evaluating Covid-19 and Therapeutic Strategies (CONNECTS) research program that enrolled 6690 participants and evaluated 18 intervention strategies using 10 molecular agents across the care continuum (outpatient, inpatient, and post discharge), and reports lessons learned from this initiative. Successes include rapid trial execution through collaboration and adaptive platform designs. Challenges that impeded efficiency included time required to execute subcontracts, constraints on clinical research workforce, and limited research infrastructure in nonacademic settings.
Source: NEJM Evidence
Authors: Sonia M. Thomas, Robert A. Harrington, Clyde W. Yancy, Diane Nugent, Serpil Erzurum, Gordon R. Bernard, Mary Cushman, Judith S. Hochman, Paul M. Ridker, Thomas L. Ortel, Sean P. Collins, Clifton W. Callaway, Tracy L. Nolen, Kelsey N. Womack, Samuel M. Brown, Annetine Gelijns, Mark Geraci, Adit A. Ginde, Nigel S. Key, Jerry A. Krishnan, Lisa LaVange, Stephen R. Wisniewski, Lisa Berdan, Antonello Punturieri, David C. Goff, Amy P. Patterson
Institutions: RTI International, Weill Cornell Medicine, Northwestern University, Children's Hospital of Orange County, Cleveland Clinic, Vanderbilt University Medical Center, University of Vermont, NYU Langone Health, New York University, Brigham and Women's Hospital, Duke University, VA Tennessee Valley Healthcare System, University of Pittsburgh, Intermountain Healthcare, University of Utah, Icahn School of Medicine at Mount Sinai, University of Colorado Anschutz, University of North Carolina at Chapel Hill, University of Illinois Chicago, National Heart, Lung, and Blood Institute
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4403633421