Work

Steroid-sparing strategy for the treatment of vasculitis associated with antineutrophil cytoplasmic antibodies

Year: 2024

Type: article

Abstract: Glucocorticoids (GC) and immunosuppressants (IS) are traditional treatments for vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA), often resulting in the development of infections, diabetes mellitus and other adverse events (AEs). The development of a steroid-sparing strategy using biologic disease-modifying antirheumatic drugs (bDMARDs, including rituximab, etc.) and synthetic targeted drugs (avacopan) has radically improved the course of the disease. Currently, there are increasing number of basic and clinical trials of numerous bDMARDs that effectively reduce the number of AEs associated with GC and IS. The steroid-sparing therapeutic strategy not only shows considerable efficacy, but also opens up new perspectives for the treatment of patients with ANCA-associated systemic vasculitis.

Source: Modern Rheumatology Journal

DOI: 10.14412/1996-7012-2024-5-107-115

Authors: O. N. Egorova, G. M. Tarasova, A. V. Datsina, B. G. Issayeva, D. S. Dilmanova, S. M Issayeva, A. M. Lila

Institutions: Association of Rheumatologists of Russia, Kazakh National Medical University, Ministry of Health of the Russian Federation

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403638311

FWCI:

Cites: 77

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Related to: 10