Severe and Persistent Thrombocytopenia in an Adolescent Girl Following Dengue Infection Manifesting As Pulmonary Hemorrhage
Year: 2024
Type: article
Study design: Case Report
Abstract: Thrombocytopenia is common in the critical phase of dengue due to decreased production from the bone marrow and increased peripheral destruction of platelets. Platelet count improves with resolution of the disease. However, further evaluation is required if thrombocytopenia persists for a longer period following dengue infection. Immune thrombocytopenic purpura (ITP) is an autoimmune hematological disorder in which antibodies bind to platelets, leading to accelerated platelet destruction, and is characterized by mucocutaneous bleeding. It may occur secondary to viral infections. We present a case of an adolescent girl with persistent severe thrombocytopenia following a dengue infection, which manifested as pulmonary hemorrhage. A bone marrow examination revealed a diagnosis of ITP, following which the child responded to steroid therapy.
Source: Cureus
DOI: 10.7759/cureus.72127
Authors: Ratan Kumar, Binod Kumar, Adyasha Mishra, Radhika Narayan, Vadde Sumitha
Institutions: Tata Main Hospital, Manipal-Tata Medical College, Jamshedpur
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403639660