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Cover Feature: Structure‐Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid‐β Aggregation (Chem. Eur. J. 58/2024)

Year: 2024

Type: article

Abstract: A new class of fluorinated benzenesulfonamide has been synthesized and characterized by their anti-amyloid potential. In their Research Article (DOI: 10.1002/chem.202402330), D. Matulis and co-workers investigate the compounds’ structure–activity relationship for inhibiting amyloid-beta (Aβ) aggregation, which is considered to be the onset of Alzheimer's disease. The synthesized molecules were effective at slowing down Aβ aggregation by extending its nucleation phase and reduced aggregate toxicity to SHSY-5Y cells.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202485804

Authors: Mantas Žvirblis, Andrius Sakalauskas, Saeid Hadi Ali Janvand, Virginija Dudutienė, Mantas Žiaunys, Rūta Sniečkutė, Daniel E. Otzen, Vytautas Smirnovas, Daumantas Matulis

Institutions: Vilnius University, Aarhus University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4403654515

FWCI:

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