Work

Probing the importance of AIF interaction with endonuclease G in mitochondrial inheritance and neurodegeneration

Year: 2024

Type: article

Abstract: Endonuclease G (EndoG) is a conserved nuclease that, under normal conditions, is found in the intermembrane space of mitochondria and plays important roles in multiple cellular processes in diverse organisms, including mitochondrial DNA (mtDNA) replication 1 , apoptosis 2 , 3 , mitochondrial maintenance 4 , neurodegeneration 5 , and paternal mitochondrial elimination (PME) 6 . Thus, identification and analysis of factors that regulate the activity of EndoG is crucial for understanding how these important cellular events are regulated.

Source: Cell Discovery

DOI: 10.1038/s41421-024-00736-2

Authors: Shanshan Li, Graham Redweik, Jason L. J. Lin, Yi-Ning Chen, Hanna S. Yuan, Ding Xue

Institutions: Tsinghua University, University of Colorado Boulder, Institute of Molecular Biology, Academia Sinica, Academia Sinica

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390