Work

Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124

Year: 2024

Type: article

Abstract: The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in complex with the competitive inhibitor SB505124 is presented. The study provides insights into the structure and function of TβR1 in complex with SB505124, and as such offers molecular-level understanding of the inhibition of this critical signalling pathway. The potential of SB505124 as an avenue for therapy in cancer treatment is discussed on basis of the results.

Source: Acta Crystallographica Section F Structural Biology Communications

DOI: 10.1107/s2053230x24010094

Authors: Jhon A. Rodriguez Buitrago, Maréne Landström, Magnus Wolf-Watz

Institution: Umeå University

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,350