Work

Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

Year: 2024

Type: article

Abstract: This review article offers an in-depth look of the cutting-edge uses of nanotechnology in glioblastoma therapy, with a particular emphasis on diagnostic approaches and drug delivery systems . This article's comprehensive examination of the interaction between nanotechnology and a variety of therapeutic modalities, such as immunotherapy , gene therapy, and chemotherapy delivery systems, is a distinctive feature. In contrast to traditional reviews, this manuscript incorporates advanced diagnostic techniques, such as MRI, PET , and nanotechnology-based imaging agents, to demonstrate their potential to enhance therapeutic efficacy and diagnostic accuracy. The article also distinctively emphasizes the obstacles presented by the blood-brain barrier (BBB) and tumor microenvironment in the treatment of glioblastoma, offering comprehensive insights into how nanotechnology can surmount these obstacles to enhance drug delivery and minimize systemic adverse effects . This review distinguishes itself by providing a comprehensive and innovative viewpoint on the management of glioblastoma, which is derived from a synthesis of both diagnostics and therapeutic advancements, as well as a forward-thinking discussion of nanotechnology's potential to address current limitations.

Source: Journal of Drug Delivery Science and Technology

DOI: 10.1016/j.jddst.2024.106322