18F-Difluoromethyl(ene) Motifs via Oxidative Fluorodecarboxylation with [18F]Fluoride
Year: 2024
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Herein, we report that α-fluorocarboxylic acids undergo manganese-mediated oxidative 18 F-fluorodecarboxylation with [ 18 F]fluoride affording biologically relevant 18 F-difluoromethyl(ene)-containing molecules. This no-carrier added process provides a solution to a known challenge in radiochemistry and expands the radiochemical space available for positron emission tomography (PET) ligand discovery. Scalability on a fully automated radiosynthetic platform is exemplified with the production of [ 18 F]4,4-difluoropiperidine that, we demonstrate, is amenable to postlabeling functionalization including N -heteroarylation and amide as well as sulfonamide bond formation.
Source: Organic Letters
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: National Science Foundation, Pfizer, AstraZeneca, GlaxoSmithKline, Novartis, Diamond Light Source, University of Oxford, Cardiff University, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Defence Science and Technology Laboratory, Defence Science and Technology Group, Cilag
OpenAlex ID: W4403682870