Work

Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice

Year: 2024

Type: article

Abstract: To our knowledge, our finding in this study shows for the first time that metabolic shifts in ratio of ucOcn to cOcn toward bone resorption are markedly correlated with age-dependent bone loss in male mice. These findings for the effects of aging on bone loss will assist in studying the pathogenesis of human type II osteoporosis.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00294.2024

Authors: Matthew Bernhard, Obinna Okorie, Wei-Ju Tseng, Mengcun Chen, Julia Danon, Mingshu Cui, Elisabeth Lashbrooks, Yanmei Yang, Bin Wang

Institution: Thomas Jefferson University

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1161274994, G1301024975, G3083555901, G4165189826, G6881548004, Biasing OGR1 signaling to optimizing PTH therapeutic effect, Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)

OpenAlex ID: W4403682947

FWCI: 0.462

Cites: 61

Cited by: 4

Related to: 10