Work

Iodine(III)-Mediated Photochemical C–H Azolation

Year: 2024

Type: article

Abstract: A systematic radical polarity analysis framework is formulated herein for the projection of radical reactivity patterns. An iodine(III)-mediated photochemical C–H azolation reaction has been envisaged and developed based on the set of empirical guidelines. The synthesis features an environmentally benign reagent, mild reaction conditions, an operationally simple protocol, and a broad substrate scope. The inclusive demonstration of reactivity for ether, thioether, amide, benzylic, and allylic C–H bonds promises wide-ranging synthetic utility.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c03490

Authors: Xuanzhen Han, Wenjie Yue, Zhixin Wang, Hanxiao Xu, Mengjie Yang, Jin Zhu

Institution: Nanjing University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, Jiangsu Science and Technology Department

Awards: G117299061, G2814365926, G6916446599