Cognitive status and demographics modify the association between subjective cognition and amyloid
Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: This study examined the effect of cognitive status, education, and sex on the association between subjective cognitive decline (SCD) and Alzheimer's disease (AD) biomarkers in non-demented older adults. METHODS: Vanderbilt Memory and Aging Project participants (n = 129), dementia or stroke free, completed fasting lumbar puncture, SCD assessment, and cognitive assessment. Cerebrospinal fluid (CSF) biomarkers for AD were analyzed. Linear regression models related SCD to CSF AD biomarkers and follow-up models assessed interactions of SCD × cognitive status, sex, reading level, and education on AD biomarkers. RESULTS: In main effect models, higher SCD was associated with more amyloidosis (p-values <0.004). SCD was not associated with tau, p-tau, or neurofilament light (NFL) levels (p-values >0.38). SCD score interacted with cognitive status (p < 0.02), sex (p = 0.03), and education (p-values <0.005) on amyloidosis. In stratified models, higher SCD was associated with more amyloid in cognitively unimpaired (p-values <0.003), men (p = 0.0003), and higher education. No SCD score × reading-level interaction was found (p-values >0.51) though SCD related to amyloid markers in the higher reading-level group (p-values <0.004). INTERPRETATION: Higher SCD was associated with greater cerebral amyloid accumulation, one of the earliest pathological AD changes. SCD appears most useful in detecting early AD-related brain changes prior to objective cognitive impairment, in men, and those with higher quantity and quality of education and highlight the importance of considering these factors.
DOI: 10.1002/acn3.52209
Institutions: Vanderbilt University Medical Center, Vanderbilt University, Sahlgrenska University Hospital, University of Gothenburg, University of Wisconsin System, University of Wisconsin–Madison, UK Dementia Research Institute, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, University College London
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,990
Funders: Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Vanderbilt University, Familjen Erling-Perssons Stiftelse, EU Joint Programme – Neurodegenerative Disease Research, National Institute for Health and Care Research, University College London, European Commission, Vetenskapsrådet, UK Dementia Research Institute, National Institutes of Health, HORIZON EUROPE Framework Programme, National Institute on Aging, National Center for Advancing Translational Sciences
Awards: G1057200632, G1088883541, G1307999793, G1343867371, G1346957673, G1451607819, G1513904913, G1546555014, G1551449788, G1588116593, G1633318100, Subjective Cognitive Decline in OIder Adults, G1710774808, G1802301745, G1928552717, G1938858119, G201353144, G2057385626, G2081597990, G2237966762, G2238434239, G2256555670, G237833635, G2475953241, G2543812357, G2799940023, G2804859505, Plasma Phosphorylated-Tau, Neurodegeneration, and Clinical Outcomes, G292763017, G3109139487, G3241251457, Fluid biomarkers for neurodegenerative dementias, G3509189227, Cognitive Complaints in Aging Adults, G3809224024, G3842727039, G3903502641, G3914690605, G401397238, G4228906844, G4234328627, G4244943609, G4260843567, G4278927122, G432431387, G434337789, G4377393254, G4425699080, G4960203590, G5040492720, G506008078, G5264190596, G5576250680, G5712520100, G5778058681, CASCADE: CAuSe or Consequence in Alzheimer DiseasE?, G6158734006, G6207287561, G6252389079, G6289970089, G6361952146, Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis, Left Ventricular Function and Mild Cognitive Impairment, G6701856265, G6745400708, G67939010, G691317373, G7075164165, G7293611571, G734120740, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G7907773732, G7972240148, G839602194, G8782684654, Vanderbilt Interdisciplinary Training Program in Alzheimer's Disease, Vanderbilt Memory & Aging Project, Vanderbilt Institute for Clinical and Translational Research (VICTR), Sex-Specific Genetic Drivers of Alzheimer's Disease Endophenotypes, G95160140
OpenAlex ID: W4403689446