Work

Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates

Year: 2024

Type: article

Abstract: Chiral oxazolidine moiety is an important core in asymmetric synthesis due to its ability to participate in various stereoselective chemical reactions and because forms a part of more complex important active compounds. Therefore, in this letter we report a convenient diastereoselective and practical strategy for the synthesis of chiral methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates starting from (R)-(–)-2-phenylglycinol and methyl propiolate which were obtained via simple two chemical and stereoselective reactions.

Source: Molbank

DOI: 10.3390/m1903

Authors: Hugo Pilotzi Xahuentitla, Jesús Guadalupe Ortega Montes, Dino Hernán Gnecco Medina, Joel Luis Terán Vazquez, Emanuel Hernández Núñez, Maria Laura Orea Flores

Institutions: Benemérita Universidad Autónoma de Puebla, Instituto Tecnológico Superior de Calkiní

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $568

Funder: Benemérita Universidad Autónoma de Puebla