Work

LC-MS guided discovery of a new type of abyssomicin, glycoabyssomicin A, from a deep-sea derived Streptomyces

Year: 2024

Type: article

Abstract: Glycoabyssomicin A (1), a new type of abyssomicin containing a sugar unit, was isolated from the deep-sea derived Streptomyces koyangensis SCSIO 5802 guided by LC-MS. The structure of 1 was elucidated by HR-ESI-MS, 1D-NMR (1H,13C NMR), 2D-NMR (HSQC, COSY, HMBC, NOESY), and TFA hydrolysis and acetylation reactions. In the antibacterial activities evaluation against a series of gram-positive and gram-negative bacteria, it showed inactive at the concentration of 10 μg per filter paper disc. This finding would broaden the way for discovery of more lead compounds of abyssomicins.

Source: Natural Product Research

DOI: 10.1080/14786419.2024.2417839

Authors: Xianglong Zhu, Songtao Wang, Yongxiang Song, Ting Chen, Yan Yan

Institutions: Chinese Academy of Sciences, South China Sea Institute Of Oceanology, University of Chinese Academy of Sciences, Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China

Awards: G3969432525, G5190696852