Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER− Breast Cancer
Year: 2024
Type: other
Abstract: S-UMAP and regional annotations identify cellular neighborhoods of interest with respect to the tumor CSC markers EpCAM and CD44v6. A, Unsupervised analysis of S-UMAP highlighting distinct EpCAM and CD44v6 expression in specific magnified regions (also shown in Fig. 5D); red box showing CD8−NOS2+COX2+ phenotype in the metastatic niche (cyan) in a stroma-restricted inflamed region; yellow and blue boxes show CD8−NOS2−COX2+ phenotypes in immune desert regions. B, Supervised analysis showing distinct EpCAM and CD4v6 expression in regions containing tumor satellites, tumor core, NOS2+ edge, lymphoid aggregates, and NOS2− edge.
Authors: Lisa A. Ridnour, William F. Heinz, Robert Y.S. Cheng, Adelaide L. Wink, Noemi Kedei, Milind Pore, Fatima Imtiaz, Elise L. Femino, Ana L. Gonzalez, Leandro L. Coutinho, Rebecca L. Moffat, Donna Butcher, Elijah F. Edmondson, Xiaoxian Li, Maria Cristina Rangel, Robert J. Kinders, Jens Rittscher, Stanley Lipkowitz, Stephen T.C. Wong, Stephen K. Anderson, Daniel W. McVicar, Sharon A. Glynn, Timothy R. Billiar, Jenny C. Chang, Stephen M. Hewitt, Stefan Ambs, Stephen J. Lockett, David A. Wink
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4403690905