Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER− Breast Cancer
Year: 2024
Type: other
Abstract: Defined CD8 NOS2 and COX2 spatial landscape. Five basic regions showing (A) margin or stroma-restricted lymphoid aggregates (orange circles) in which a gap of 50 μm (double orange arrow) between CD3+ T-cell aggregates and the CKSOX10+ tumor edge (green circle) was observed. Blue and dashed magenta circles identify immune desert regions lacking CD8+ T cells. B, Tumor fragmentation or satellite region. C, Tumor edge with proximal stroma regions. D, Significant differences in % cell composition is shown for CD8+ T cells as well as (E) NOS2+ and (F) COX2+ tumor cells. G, Graphic summary of tumor NOS2/COX2 landscape and CD8+ T-cell regional distributions with respect to the tumor–stroma interface. H, Spatial architecture of predictive phenotypes in tumors from deceased vs. alive patients. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.
Authors: Lisa A. Ridnour, William F. Heinz, Robert Y.S. Cheng, Adelaide L. Wink, Noemi Kedei, Milind Pore, Fatima Imtiaz, Elise L. Femino, Ana L. Gonzalez, Leandro L. Coutinho, Rebecca L. Moffat, Donna Butcher, Elijah F. Edmondson, Xiaoxian Li, Maria Cristina Rangel, Robert J. Kinders, Jens Rittscher, Stanley Lipkowitz, Stephen T.C. Wong, Stephen K. Anderson, Daniel W. McVicar, Sharon A. Glynn, Timothy R. Billiar, Jenny C. Chang, Stephen M. Hewitt, Stefan Ambs, Stephen J. Lockett, David A. Wink
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4403690918