Work

Biomarkers of renal parenchymal damage in young children with congenital hydronephrosis: literature review

Year: 2024

Type: article

Abstract: Enlargement of the renal cavity system in a fetus is revealed at prenatal ultrasound in 1–5% of cases and can be caused by congenital hydronephrosis due to pelvic-ureteral junction obstruction, which is one of the most common nosologies in the structure of obstructive uropathies in childhood. A high risk of renal function decrease at the preclinical stage of disease development dictates a need to create highly informative diagnostic programs and treatment algorithms aimed at preventing complications. In this review, we discuss results of studies on diagnostic and prognostic value of cytokine biomarkers which are of a great interest in congenital hydronephrosis in young children. They include: kidney injury molecule-1, vascular endothelial growth factor-A, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin, interleukin-1. Literature search for this review was made in Web of Science, PubMed, Russian Science Citation Index, CyberLeninka, Scopus databases.

Source: Russian Journal of Pediatric Surgery

DOI: 10.17816/ps795

Authors: Vladislav N. Klimov, Lyudmila A. Deryugina, Elena I. Krasnova, Era B. Popyhova, Dzhalal F. Kazymov

Institution: Saratov State Medical University

Language: English

Topic: Pediatric Urology and Nephrology Studies

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403701318

FWCI:

Cites: 58

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Related to: 10