Year: 2024
Type: article
Study design: Case Report
Abstract: Polycythemia vera (PV) is classified as a myeloproliferative neoplasm (MPN), a group of hematologic disorders. In PV, thrombosis is a leading cause of morbidity and mortality; however, hemorrhage is also a potentially life-threatening complication. The mechanisms of bleeding in PV are complex and multifactorial, including disturbances in platelet aggregation, vascular endothelial function and von Willebrand factor activity. Despite this, there are limited reports on the incidence of hyperfibrinolysis in PV and its role in bleeding events. We present a case of a PV patient with severe bleeding which was linked to both hypocoagulability and hyperfibrinolysis. We propose that PV patients with hemorrhage should be evaluated for all potential coagulation disorders, including hyperfibrinolysis, to ensure optimal patient care.
Source: Y HOC TP HO CHI MINH
Authors: Tram Bich Huynh-Duong, Tuan Huu Nguyen, Tung Thanh Tran, Thanh-Thang Thi Nguyen, Tuyen Ngoc Le
Institution: Cho Ray Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403701945