Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects
Year: 2024
Type: article
Study design: Observational Study
Abstract: The implication of Torquetenovirus (TTV) in ischemic heart disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, pro-inflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects and 86 individuals with IHD (aged 55-75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with non-IHD (aged 65-96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension, and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.42-4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32-10.39). In a RASIG subgroup, individuals with TTV viremia ≥4 log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia <4 log. No significant difference in cytokine production was observed between IHD patients and non-IHD with TTV viremia ≥4 log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4 log displayed higher NLR and SIRI index than those with TTV viremia <4 log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented pro-inflammatory response and immunosenescence.
Authors: Robertina Giacconi, Francesco Piacenza, Fabrizio Maggi, Alexander Bürkle, María Moreno-Villanueva, Lucia Mancinelli, Pietro Giorgio Spezia, Federica Novazzi, Francesca Drago Ferrante, Claudia Minosse, Paolo Antonio Grossi, Nicasio Mancini, Monia Cecati, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Claudio Franceschi, Miriam Capri, Birgit Weinberger, Ewa Sikora, Florence Debacq-Chainiaux, Wolfgang Stuetz, Mikko Hurme, P Eline Slagboom, Jürgen Bernhardt, Davide Gentilini, Luciano Calzari, Mirko Di Rosa, Anna Rita Bonfigli, Roberta Galeazzi, Antonio Cherubini, Fabrizia Lattanzio, Mauro Provinciali, Marco Malavolta
Institutions: Istituto Nazionale di Riposo e Cura per Anziani, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, University of Konstanz, University of Insubria, Aziende Socio Sanitarie Territoriale dei Sette Laghi, National Institute for Public Health and the Environment, German Institute of Human Nutrition, National Hellenic Research Foundation, N. I. Lobachevsky State University of Nizhny Novgorod, University of Bologna, Universität Innsbruck, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polish Academy of Sciences, University of Namur, Namur Research Institute for Life Sciences, University of Hohenheim, Tampere University, University of Tampere, Leiden University, Leiden University Medical Center, BioTeSys (Germany), University of Pavia, IRCCS Istituto Auxologico Italiano, Marche Polytechnic University
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,628
Funders: European Commission, NextGenerationEU
OpenAlex ID: W4403707201