Work

Furfural: An Efficient Platform Molecule as a CO Surrogate in Palladium Catalysed Synthesis of α, β‐Alkynylamides

Year: 2024

Type: article

Abstract: Biomass‐derived furfural was used as a CO surrogate for the first time in the oxidative N‐dealkylation/carbonylation of various aliphatic and cyclic tertiary amines with terminal alkynes to produce alk‐2‐ynamides. This reaction employed O2 as an ideal oxidising agent and used a Pd/C catalyst with KI as an additive in a base free and ligand free condition. Notably, the selective sp3 C−N bond cleavage of tertiary amines led to its potential application as an amine source. The typical and simple route provides another option for producing a broad variety of alk‐2‐ynamide derivatives in environmentally friendly and efficient way under mild conditions. This method also displays notable reusability.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202400507

Authors: Shraddha D. Shinde, Nina Kuchkina, Bhalchandra M. Bhanage, Zinaida Shifrina

Institutions: Institute of Chemical Technology, Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Russian Science Foundation