Work

Pediatric cognitive reserve moderates the effect of brain structure in attention-deficit/hyperactivity disorder: Evidence for an optimized residual approach.

Year: 2024

Type: article

Abstract: OBJECTIVE: To validate a residual-based cognitive reserve (CR) index optimized for a pediatric sample with attention-deficit/hyperactivity disorder (ADHD). METHOD: = 43 (37.4%) met criteria for ADHD. Elastic-net regularized linear regression was used to generate baseline and longitudinal CR indices by maximally residualizing variance in fluid intelligence for demographics and brain structure. Academic and diagnostic outcomes were regressed onto CR indices, and interactions with brain integrity were assessed. RESULTS: = .048). CONCLUSIONS: A data-driven residual approach to operationalizing pediatric CR shows better evidence of construct validity over previous methods, with our index showing a novel ability to moderate the deleterious effects of lower grey matter on outcomes in ADHD. This approach may benefit future research aiming to study the early development of CR. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Source: Neuropsychology

DOI: 10.1037/neu0000978

Authors: Zubin A. Irani, Andrew M. C. Sheridan, Vicki Anderson, Timothy J. Silk, Michael Weinborn, Brandon E. Gavett

Institutions: The University of Western Australia, Murdoch Children's Research Institute, University of California, Davis

Language: English

Topic: Attention Deficit Hyperactivity Disorder

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Western Australia, Collier Charitable Fund, National Health and Medical Research Council