Work

Hyperhomocysteinemia Causing Vascular Occlusion and Complicated by Heparin-Induced Thrombocytopenia and Gastrointestinal Bleed

Year: 2024

Type: article

Abstract: Homocysteine, an intermediate amino acid, is involved in methionine metabolism, which is crucial for various physiological pathways, including protein synthesis and DNA methylation. Elevated levels of homocysteine have been implicated as both a modifiable and unmodifiable risk factor in cardiovascular disease, influencing atherosclerotic disease formation and hypercoagulability. Mechanisms linking elevated homocysteine levels to vascular occlusion involve endothelial dysfunction, inflammation, and enhanced thrombotic potential. We present the case of a 54-year-old female with hyperhomocysteinemia-induced hypercoagulability causing acute limb ischemia, necessitating below-knee amputation.

Source: Cureus

DOI: 10.7759/cureus.72318

Authors: Brooke A Finlayson, Megan Brooker, Marielle Roberts-McDonald, Penelope Mashburn

Institutions: Ross University School of Medicine, Northeast Ohio Medical University

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403718782