Work

Prevalence and Significance of Pancreatic Iron in Transfusion‐Dependent Sickle Cell Disease

Year: 2025

Type: article

Study design: Observational Study

Abstract: BACKGROUND: Chronically transfused patients with sickle cell disease (SCD) and beta thalassemia major (TM) develop iron overload. OBJECTIVE: Determine the impact of iron overload on glucose regulation in SCD. METHODS: * measurements and oral glucose tolerance tests. RESULTS: Impaired fasting glucose (2 vs. 9, p = 0.27) and impaired glucose tolerance (1 vs. 11, p = 0.019) were less common in patients with SCD compared with patients with TM. No SCD patient had diabetes. CONCLUSION: Iron-mediated glucose dysregulation is present but less common in SCD patients.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.31780

Authors: Akhila Vadivelan, Eamon Doyle, Susan Carson, Christopher Denton, Saranya Veluswamy, Thomas Hofstra, Thomas Coates, John C. Wood

Institutions: University of California, Los Angeles, Mattel Children's Hospital, University of Southern California, Children's Hospital Los Angeles

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Philips Medical Systems, National Institutes of Health, Saban Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences

Awards: G5919997565, Optimizing Tissue Iron Quantification at 3 Tesla, Southern California Clinical and Translational Science Institute

OpenAlex ID: W4410333260

FWCI: 0.641

Cites: 8

Cited by: 1

Related to: 10