Year: 2024
Type: article
Study design: Observational Study
Abstract: Thromboembolic complications are common in severe COVID-19 and are thought to result from excessive neutrophil-extracellular-trap (NET)-driven immunothrombosis. Glycosylation plays a vital role in the efficiency of immunoglobulin A (IgA) effector functions, with significant implications for NET formation in infectious diseases. This study represents the first comprehensive analysis of plasma IgA glycosylation during severe SARS-CoV-2 or Influenza A infection, revealing lower sialylation and higher galactosylation of IgA1 O-glycans in acute respiratory distress syndrome (ARDS), regardless of the underlying cause of the disease. Importantly, N-glycans displayed an infection-specific pattern, with N47 of IgA2 showing diminished sialylation and bisection, and N340/N327 of IgA1/2 demonstrating lower fucosylation and antennarity along with higher non-complex glycans in COVID-19 compared to Influenza. Notably, COVID-19 IgA possessed strong ability to induce NET formation and its glycosylation patterns correlated with extracellular DNA levels in plasma of critically ill COVID-19 patients. Our data underscores the necessity of further research on the role of IgA glycosylation in the modulation of pathogen-specific immune responses in COVID-19 and other infectious diseases.
Source: Frontiers in Immunology
Authors: Daniel P. Potaczek, Bianca D. M. van Tol, David Falck, Christina Krolczik, Kristina Zlatina, Wilhelm Bertrams, Jochen Wilhelm, Bernd Schmeck, Benjamin Seeliger, Sascha David, Chrysanthi Skevaki, Elisabeth Mack, Werner Seeger, Liliana Schaefer, Sebastian P. Galuska, Manfred Wuhrer, Małgorzata Wygrecka
Institutions: Philipps University of Marburg, German Center for Lung Research, Universities of Giessen and Marburg Lung Center, Leiden University Medical Center, Research Institute for Farm Animal Biology (FBN), Justus-Liebig-Universität Gießen, Medizinische Hochschule Hannover, University of Zurich, University Hospital Zurich, Goethe University Frankfurt
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4403733925