Work

Intraperitoneal versus intravenous administration of Flamma®-conjugated PEG-alendronate-coated upconversion nanoparticles in a mouse pancreatic cancer model

Year: 2024

Type: article

Abstract: intravenous administration was then compared in terms of biodistribution of particles in various organs in the orthotopic mice pancreatic cancer model. The intraperitoneal route was preferred over the intravenous one, because it significantly increased the accumulation of particles in the tumor tissue. These new UCNP@Ale-PEG-Flamma® nanoparticles are thus promising for new treatment avenues for pancreatic cancer.

Source: Nanoscale Advances

DOI: 10.1039/d4na00764f

Authors: Taras Vasylyshyn, Vitalii Patsula, David Větvička, Oleksandr Shapoval, Jan Pankrác, Martina Kabešová, Jiří Beneš, Daniel Horák

Institutions: Czech Academy of Sciences, Czech Academy of Sciences, Institute of Macromolecular Chemistry, Charles University, Center for Advanced Preclinical Imaging

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: Univerzita Karlova v Praze, Ministerstvo Školství, Mládeže a Tělovýchovy, Grantová Agentura České Republiky

Awards: National Infrastructure for Biological and Medical Imaging, Surface-engineered upconversion nanoparticles for quantitative diagnostics of pancreatic β-cells in diabetology by MRI, fluorescence and microscopy

OpenAlex ID: W4403749053

FWCI: 0.845

Cites: 32

Cited by: 10

Related to: 10