Work

ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR

Year: 2024

Type: article

Abstract: mice exhibit disrupted spermatogenesis and reduced testicular circRNA levels. Additionally, expression levels of human ZC3H14 are associated with non-obstructive azoospermia. Our findings reveal a conserved requirement for ZC3H14 in the modulation of backsplicing and link ZC3H14 and circRNA biogenesis to male fertility.

Source: Molecular Cell

DOI: 10.1016/j.molcel.2024.10.001

Authors: Qiqi Li, Gang Yang, Bingbing Ren, Xu Liu, Li-Qin Tang, Qinghua Shi, Ge Shan, Xiaolin Wang

Institutions: University of Science and Technology of China, Hefei National Center for Physical Sciences at Nanoscale, Sir Run Run Shaw Hospital, Zhejiang University

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $9,350

Funders: National Natural Science Foundation of China, National University's Basic Research Foundation of China, Fundamental Research Funds for the Central Universities

OpenAlex ID: W4403762758

FWCI: 3.693

Cites: 105

Cited by: 32

Related to: 10